Facing unprecedented population-ageing, the growing impact of noncommunicable diseases (NCDs) necessitates transformation in a contemporary healthcare system. To shift a diagnostics landscape from a centralized laboratory closer to patients in a point-of-use (PoU) setting, a magnetoresistive biosensing technology is proposed. This magnetic biosensor array, integrated with CMOS ICs, can better address hardware challenges in NCD management, since it provides matrix-insensitivity, rapid turnaround time, and miniaturization without a loss of sensitivity. In this talk, magneto-biosensing technologies are validated in both cellular and molecular assays. A magnetic flow cytometer (MFC) using giant magnetoresistive (GMR) devices and matched filtering is developed to perform aptamer-based cancer cell detection, exhibiting an affordable signal-to-noise ratio (SNR) down to 2.5 dB. To move toward wearable applications, magnetorelaxometry (MRX) is implemented with GMR sensors and bioelectronics, demonstrating the first realization of GMR-based time-domain MRX bioassays.

Chih-Cheng (Iric) Huang is currently an assistant professor of Precision Medicine Program, National Tsing Hua University (NTHU). He received the B.S. degree in materials science and engineering from National Taiwan University (NTU) in 2010, the M.S. degree in nanoengineering and microsystems from NTHU in 2012, and the Ph.D. degree in materials science and engineering from the University of California – San Diego (UCSD) in 2020. Dr. Huang extensively researches cutting-edge semiconductor devices and their applications on biosensors and bioelectronics, by which precision diagnostics transforms the healthcare system from a one-size-fits-all model to a personalized framework. Since 2010, he has cross-disciplinarily worked on III-V compound, high electron mobility transistors (HEMTs), magnetoresistive devices, nanomaterials, BioMEMS, biomedical signal processing, cancer diagnostics, and targeted proteomics.